Be sure to build/factor a method for dilating the pupil, as that needs to be a big part of close-up imagery! I'm assuming you're going to do it via blendshapes?Did you watch The Texas Chainsaw Massacre (1976) the other day? That's got some great, very expressionist close-up eye shots.
@Tom: yes I think blend shapes would be easiest way. And I thought about dilating the pupil. Eye is very important for my animation, so I would want to animate it properly. And no I did not see that movie I think so. Well sorted I have I movie before I go to sleep!